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[[Image:3arn.png|left|200px]]


{{STRUCTURE_3arn|  PDB=3arn  |  SCENE=  }}
==Human dUTPase in complex with novel uracil derivative==
 
<StructureSection load='3arn' size='340' side='right'caption='[[3arn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Human dUTPase in complex with novel uracil derivative===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3arn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARN FirstGlance]. <br>
{{ABSTRACT_PUBMED_22339362}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSJ:N-{5-[(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHOXY]-2-METHYLPENTAN-2-YL}BENZENESULFONAMIDE'>MSJ</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3arn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3arn OCA], [https://pdbe.org/3arn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3arn RCSB], [https://www.ebi.ac.uk/pdbsum/3arn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3arn ProSAT]</span></td></tr>
[[3arn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARN OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>


==See Also==
==See Also==
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
*[[DUTPase 3D structures|DUTPase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022339362</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: DUTP diphosphatase]]
[[Category: Large Structures]]
[[Category: Chong, K T.]]
[[Category: Chong KT]]
[[Category: Fukuoka, M.]]
[[Category: Fukuoka M]]
[[Category: Miyahara, S.]]
[[Category: Miyahara S]]
[[Category: Miyakoshi, H.]]
[[Category: Miyakoshi H]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Latest revision as of 17:01, 13 March 2024

Human dUTPase in complex with novel uracil derivativeHuman dUTPase in complex with novel uracil derivative

Structural highlights

3arn is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUT_HUMAN This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[1]

See Also

References

  1. ↑ Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593

3arn, resolution 1.80Å

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