3a1y: Difference between revisions

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[[Image:3a1y.png|left|200px]]


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==The structure of archaeal ribosomal stalk P1/P0 complex==
The line below this paragraph, containing "STRUCTURE_3a1y", creates the "Structure Box" on the page.
<StructureSection load='3a1y' size='340' side='right'caption='[[3a1y]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3a1y]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1y OCA], [https://pdbe.org/3a1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1y RCSB], [https://www.ebi.ac.uk/pdbsum/3a1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1y ProSAT]</span></td></tr>
{{STRUCTURE_3a1y|  PDB=3a1y  |  SCENE=  }}
</table>
 
== Function ==
===The structure of protein complex===
[https://www.uniprot.org/uniprot/RL12_PYRHO RL12_PYRHO] Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.<ref>PMID:17804412</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1y_consurf.spt"</scriptWhenChecked>
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a1y ConSurf].
[[3a1y]] is a 7 chain structure of [[Ribosomal protein L10]] with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1Y OCA].  
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L10]]
*[[Ribosomal protein L10|Ribosomal protein L10]]
 
*[[Ribosomal protein P0|Ribosomal protein P0]]
==Reference==
*[[Ribosomal protein P1|Ribosomal protein P1]]
<ref group="xtra">PMID:20007716</ref><references group="xtra"/>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Naganuma, T.]]
[[Category: Naganuma T]]
[[Category: Nomura, N.]]
[[Category: Nomura N]]
[[Category: Tanaka, I.]]
[[Category: Tanaka I]]
[[Category: Uchiumi, T.]]
[[Category: Uchiumi T]]
[[Category: Yao, M.]]
[[Category: Yao M]]
[[Category: Yu, J.]]
[[Category: Yu J]]
[[Category: Helix spin]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
[[Category: Stalk]]

Latest revision as of 16:59, 13 March 2024

The structure of archaeal ribosomal stalk P1/P0 complexThe structure of archaeal ribosomal stalk P1/P0 complex

Structural highlights

3a1y is a 7 chain structure with sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.13Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RL12_PYRHO Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Maki Y, Hashimoto T, Zhou M, Naganuma T, Ohta J, Nomura T, Robinson CV, Uchiumi T. Three binding sites for stalk protein dimers are generally present in ribosomes from archaeal organism. J Biol Chem. 2007 Nov 9;282(45):32827-33. Epub 2007 Sep 5. PMID:17804412 doi:http://dx.doi.org/10.1074/jbc.M705412200

3a1y, resolution 2.13Å

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