7kpw: Difference between revisions
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New page: '''Unreleased structure''' The entry 7kpw is ON HOLD Authors: Description: Category: Unreleased Structures |
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The | ==Structure of the H-lobe of yeast CKM== | ||
<StructureSection load='7kpw' size='340' side='right'caption='[[7kpw]], [[Resolution|resolution]] 4.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7kpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KPW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kpw OCA], [https://pdbe.org/7kpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kpw RCSB], [https://www.ebi.ac.uk/pdbsum/7kpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kpw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SRB8_YEAST SRB8_YEAST] Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.<ref>PMID:12200444</ref> <ref>PMID:15601835</ref> <ref>PMID:16076843</ref> <ref>PMID:16109375</ref> | |||
==See Also== | |||
*[[Mediator|Mediator]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Boyer TG]] | |||
[[Category: Chang CE]] | |||
[[Category: Chao TC]] | |||
[[Category: Chen SF]] | |||
[[Category: Cholko T]] | |||
[[Category: Garcia BA]] | |||
[[Category: Kim HJ]] | |||
[[Category: Li YC]] | |||
[[Category: Murakami K]] | |||
[[Category: Nakanishi K]] | |||
[[Category: Tsai KL]] | |||
Latest revision as of 17:57, 6 March 2024
Structure of the H-lobe of yeast CKMStructure of the H-lobe of yeast CKM
Structural highlights
FunctionSRB8_YEAST Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.[1] [2] [3] [4] See AlsoReferences
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