4qnh: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 4qnh is ON HOLD Authors: Zhang, M., Pascal, J.M., Logothetis, D.E., Zhang. J.F. Description: Calcium-calmodulin (T79D) complexed with the calmoduli... |
No edit summary |
||
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a== | ||
<StructureSection load='4qnh' size='340' side='right'caption='[[4qnh]], [[Resolution|resolution]] 2.02Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QNH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qnh OCA], [https://pdbe.org/4qnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qnh RCSB], [https://www.ebi.ac.uk/pdbsum/4qnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qnh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. | |||
==See Also== | |||
*[[Calmodulin 3D structures|Calmodulin 3D structures]] | |||
*[[Potassium channel 3D structures|Potassium channel 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Logothetis DE]] | |||
[[Category: Pascal JM]] | |||
[[Category: Zhang JF]] | |||
[[Category: Zhang M]] | |||
Latest revision as of 15:47, 1 March 2024
Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-aCalcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a
Structural highlights
FunctionKCNN2_RAT Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. See Also |
| ||||||||||||||||||