4obv: Difference between revisions

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-'''Unreleased structure'''
-The entry 4obv is ON HOLD
+==Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)==
+<StructureSection load='4obv' size='340' side='right'caption='[[4obv]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
-Authors: Fraser, J.S., Van Benschoten, A.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4obv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruminococcus_gnavus_ATCC_29149 Ruminococcus gnavus ATCC 29149]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OBV FirstGlance]. <br>
-Description: Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2SU:ALPHA-(FLUOROMETHYL)-D-TRYPTOPHAN'>2SU</scene>, <scene name='pdbligand=3SO:{5-HYDROXY-4-[(1E)-4-(1H-INDOL-3-YL)-3-OXOBUT-1-EN-1-YL]-6-METHYLPYRIDIN-3-YL}METHYL+DIHYDROGEN+PHOSPHATE'>3SO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4obv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4obv OCA], [https://pdbe.org/4obv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4obv RCSB], [https://www.ebi.ac.uk/pdbsum/4obv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4obv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRPDC_RUMGV TRPDC_RUMGV] Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) may influence host brain and behavior. Has weak activity with tyrosine and phenylalanine.<ref>PMID:25263219</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Fraser JS]]
+[[Category: Van Benschoten AH]]