4obv

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Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)

Structural highlights

4obv is a 4 chain structure with sequence from Ruminococcus gnavus ATCC 29149. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.84Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRPDC_RUMGV Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) may influence host brain and behavior. Has weak activity with tyrosine and phenylalanine.[1]

References

  1. ↑ Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA. Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine. Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001., Epub 2014 Sep 25. PMID:25263219 doi:http://dx.doi.org/10.1016/j.chom.2014.09.001

4obv, resolution 2.84Å

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OCA
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