4nn1: Difference between revisions
New page: '''Unreleased structure''' The entry 4nn1 is ON HOLD Authors: Nitin Kumar, Abhijith Radhakrishnan, Tsung-Han Chou, Edward Yu Description: Crystal Structure of transcriptional regulator... |
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==Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis== | |||
<StructureSection load='4nn1' size='340' side='right'caption='[[4nn1]], [[Resolution|resolution]] 2.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4nn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NN1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn1 OCA], [https://pdbe.org/4nn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4nn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RAAS_MYCTU RAAS_MYCTU] Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658).<ref>PMID:24424575</ref> <ref>PMID:24590482</ref> <ref>PMID:25012658</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Chou T-H]] | |||
[[Category: Kumar N]] | |||
[[Category: Radhakrishnan A]] | |||
[[Category: Yu E]] | |||