4lmg: Difference between revisions

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'''Unreleased structure'''


The entry 4lmg is ON HOLD
==Crystal structure of AFT2 in complex with DNA==
<StructureSection load='4lmg' size='340' side='right'caption='[[4lmg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lmg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LMG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmg OCA], [https://pdbe.org/4lmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lmg RCSB], [https://www.ebi.ac.uk/pdbsum/4lmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lmg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AFT2_YEAST AFT2_YEAST] Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.<ref>PMID:11448968</ref> <ref>PMID:11734641</ref> <ref>PMID:12756250</ref> <ref>PMID:15649888</ref> <ref>PMID:16024809</ref>


Authors: Poor, C.B., Sanishvili, R., Schuermann, J.P., He, C.
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
Description: AFT2P-DNA
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: He C]]
[[Category: Poor CB]]
[[Category: Sanishvili R]]
[[Category: Schuermann JP]]

Latest revision as of 15:20, 1 March 2024

Crystal structure of AFT2 in complex with DNACrystal structure of AFT2 in complex with DNA

Structural highlights

4lmg is a 8 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AFT2_YEAST Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.[1] [2] [3] [4] [5]

See Also

References

  1. ↑ Blaiseau PL, Lesuisse E, Camadro JM. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem. 2001 Sep 7;276(36):34221-6. Epub 2001 Jul 11. PMID:11448968 doi:http://dx.doi.org/10.1074/jbc.M104987200
  2. ↑ Rutherford JC, Jaron S, Ray E, Brown PO, Winge DR. A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14322-7. PMID:11734641 doi:http://dx.doi.org/10.1073/pnas.261381198
  3. ↑ Rutherford JC, Jaron S, Winge DR. Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem. 2003 Jul 25;278(30):27636-43. Epub 2003 May 19. PMID:12756250 doi:http://dx.doi.org/10.1074/jbc.M300076200
  4. ↑ Rutherford JC, Ojeda L, Balk J, Muhlenhoff U, Lill R, Winge DR. Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2005 Mar 18;280(11):10135-40. Epub 2005 Jan 13. PMID:15649888 doi:http://dx.doi.org/10.1074/jbc.M413731200
  5. ↑ Courel M, Lallet S, Camadro JM, Blaiseau PL. Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol. 2005 Aug;25(15):6760-71. PMID:16024809 doi:http://dx.doi.org/25/15/6760

4lmg, resolution 2.20Å

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