4l4s: Difference between revisions

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New page: '''Unreleased structure''' The entry 4l4s is ON HOLD Authors: Dempster, S., Harper, S., Moses, J.E., Dreveny, I. Description: Structural Characterisation of the Apo-form of Human Lacta...
 
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'''Unreleased structure'''


The entry 4l4s is ON HOLD
==Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme==
<StructureSection load='4l4s' size='340' side='right'caption='[[4l4s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4l4s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4s OCA], [https://pdbe.org/4l4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4s RCSB], [https://www.ebi.ac.uk/pdbsum/4l4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4s ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
== Function ==
[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]


Authors: Dempster, S., Harper, S., Moses, J.E., Dreveny, I.
==See Also==
 
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
Description: Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dempster S]]
[[Category: Dreveny I]]
[[Category: Harper S]]
[[Category: Moses JE]]

Latest revision as of 15:17, 1 March 2024

Structural characterisation of the NADH binary complex of human lactate dehydrogenase M isozymeStructural characterisation of the NADH binary complex of human lactate dehydrogenase M isozyme

Structural highlights

4l4s is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

LDHA_HUMAN Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]

Function

LDHA_HUMAN

See Also

References

  1. ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430

4l4s, resolution 2.90Å

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