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{{STRUCTURE_4it0|  PDB=4it0  |  SCENE=  }}
===Structure of the RNA ligase RtcB-GMP/Mn(II) complex===
{{ABSTRACT_PUBMED_23560983}}


==Function==
==Structure of the RNA ligase RtcB-GMP/Mn(II) complex==
[[http://www.uniprot.org/uniprot/RTCB_PYRHO RTCB_PYRHO]] tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity).  
<StructureSection load='4it0' size='340' side='right'caption='[[4it0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4it0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IT0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4it0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4it0 OCA], [https://pdbe.org/4it0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4it0 RCSB], [https://www.ebi.ac.uk/pdbsum/4it0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4it0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RTCB_PYRHO RTCB_PYRHO] tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity).


==About this Structure==
==See Also==
[[4it0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii_ot3 Pyrococcus horikoshii ot3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IT0 OCA].
*[[RNA ligase|RNA ligase]]
[[Category: Pyrococcus horikoshii ot3]]
__TOC__
[[Category: Bingman, C A.]]
</StructureSection>
[[Category: Desai, K K.]]
[[Category: Large Structures]]
[[Category: Phillips, G N.]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Raines, R T.]]
[[Category: Bingman CA]]
[[Category: Ligase]]
[[Category: Desai KK]]
[[Category: Rna ligase]]
[[Category: Phillips Jr GN]]
[[Category: Raines RT]]

Latest revision as of 14:59, 1 March 2024

Structure of the RNA ligase RtcB-GMP/Mn(II) complexStructure of the RNA ligase RtcB-GMP/Mn(II) complex

Structural highlights

4it0 is a 2 chain structure with sequence from Pyrococcus horikoshii OT3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RTCB_PYRHO tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity).

See Also

4it0, resolution 2.40Å

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