4ezt: Difference between revisions
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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)== | |||
<StructureSection load='4ezt' size='340' side='right'caption='[[4ezt]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ezt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Heliothis_virescens Heliothis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezt OCA], [https://pdbe.org/4ezt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezt RCSB], [https://www.ebi.ac.uk/pdbsum/4ezt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] | |||
==See Also== | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Heliothis virescens]] | |||
[[Category: Large Structures]] | |||
[[Category: Straeter N]] | |||
[[Category: Zahn M]] | |||
Latest revision as of 14:07, 1 March 2024
Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)
Structural highlights
FunctionDNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] See Also |
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