3v8r: Difference between revisions

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==Crystal structure of NAD kinase 1 H223E mutant from Listeria monocytogenes in complex with 5'-amino-8-bromo-5'-deoxyadenosine==
The line below this paragraph, containing "STRUCTURE_3v8r", creates the "Structure Box" on the page.
<StructureSection load='3v8r' size='340' side='right'caption='[[3v8r]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3v8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NB:5-AMINO-8-BROMO-5-DEOXYADENOSINE'>5NB</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
{{STRUCTURE_3v8r|  PDB=3v8r  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8r OCA], [https://pdbe.org/3v8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8r RCSB], [https://www.ebi.ac.uk/pdbsum/3v8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref>  


===Crystal structure of NAD kinase 1 H223E mutant from Listeria monocytogenes in complex with 5'-amino-8-bromo-5'-deoxyadenosine===
==See Also==
 
*[[NAD kinase|NAD kinase]]
 
== References ==
==About this Structure==
<references/>
[[3v8r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8R OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Listeria monocytogenes]]
[[Category: Listeria monocytogenes]]
[[Category: Assairi, L.]]
[[Category: Assairi L]]
[[Category: Dugu, L.]]
[[Category: Dugu L]]
[[Category: Dussurget, O.]]
[[Category: Dussurget O]]
[[Category: Gelin, M.]]
[[Category: Gelin M]]
[[Category: Huteau, V.]]
[[Category: Huteau V]]
[[Category: Labesse, G.]]
[[Category: Labesse G]]
[[Category: Morellato, L.]]
[[Category: Morellato L]]
[[Category: Pochet, S.]]
[[Category: Pochet S]]
[[Category: Poncet-Montange, G.]]
[[Category: Poncet-Montange G]]
[[Category: Inorganic polyphosphate/atp-nad kinase 1]]
[[Category: Ligand-screening by crystallography]]
[[Category: Transferase]]
[[Category: Two-domain kinase]]

Latest revision as of 13:34, 1 March 2024

Crystal structure of NAD kinase 1 H223E mutant from Listeria monocytogenes in complex with 5'-amino-8-bromo-5'-deoxyadenosineCrystal structure of NAD kinase 1 H223E mutant from Listeria monocytogenes in complex with 5'-amino-8-bromo-5'-deoxyadenosine

Structural highlights

3v8r is a 1 chain structure with sequence from Listeria monocytogenes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.39Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NADK1_LISMO Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361][1] [2]

See Also

References

  1. ↑ Poncet-Montange G, Assairi L, Arold S, Pochet S, Labesse G. NAD kinases use substrate-assisted catalysis for specific recognition of NAD. J Biol Chem. 2007 Nov 23;282(47):33925-34. Epub 2007 Aug 8. PMID:17686780 doi:10.1074/jbc.M701394200
  2. ↑ Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugue L, Dussurget O, Pochet S, Labesse G. Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound. Structure. 2012 May 16. PMID:22608967 doi:10.1016/j.str.2012.03.024

3v8r, resolution 2.39Å

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