3s6x: Difference between revisions

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[[Image:3s6x.jpg|left|200px]]


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==Structure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose==
The line below this paragraph, containing "STRUCTURE_3s6x", creates the "Structure Box" on the page.
<StructureSection load='3s6x' size='340' side='right'caption='[[3s6x]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3s6x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S6X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
{{STRUCTURE_3s6x|  PDB=3s6x  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s6x OCA], [https://pdbe.org/3s6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s6x RCSB], [https://www.ebi.ac.uk/pdbsum/3s6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s6x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.


===Structure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose===
==See Also==
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
__TOC__
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</StructureSection>
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[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21829363 is the PubMed ID number.
[[Category: Mammalian orthoreovirus 3 Dearing]]
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[[Category: Dermody TS]]
{{ABSTRACT_PUBMED_21829363}}
[[Category: Reiter DM]]
 
[[Category: Stehle T]]
==About this Structure==
[[3s6x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S6X OCA].
 
==Reference==
<ref group="xtra">PMID:021829363</ref><references group="xtra"/>
[[Category: Mammalian orthoreovirus 3]]
[[Category: Dermody, T S.]]
[[Category: Reiter, D M.]]
[[Category: Stehle, T.]]
[[Category: Beta-barrel]]
[[Category: Beta-spiral repeat]]
[[Category: Greek key motif]]
[[Category: Sialic acid receptors junctional adhesion molecule some]]
[[Category: Trimer]]
[[Category: Triple beta-spiral]]
[[Category: Viral attachment protein]]
[[Category: Viral capsid]]
[[Category: Viral protein]]

Latest revision as of 12:47, 1 March 2024

Structure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactoseStructure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose

Structural highlights

3s6x is a 3 chain structure with sequence from Mammalian orthoreovirus 3 Dearing. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SIGM1_REOVD Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.

See Also

3s6x, resolution 2.25Å

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