3s6x

Structure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactoseStructure of reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose

Structural highlights 3s6x is a 3 chain structure with sequence from Mammalian orthoreovirus 3 Dearing. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.25Å Ligands: , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIGM1_REOVD Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. See Also Virus coat proteins 3D structures

spinqualitylabelsall models 3s6x, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image