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{{STRUCTURE_3q5f|  PDB=3q5f  |  SCENE=  }}
===Crystal structure of the Salmonella transcriptional regulator SlyA in complex with DNA===
{{ABSTRACT_PUBMED_21550983}}


==Function==
==Crystal structure of the Salmonella transcriptional regulator SlyA in complex with DNA==
[[http://www.uniprot.org/uniprot/SLYA_SALTY SLYA_SALTY]] Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.<ref>PMID:8544813</ref> <ref>PMID:9284144</ref>
<StructureSection load='3q5f' size='340' side='right'caption='[[3q5f]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3q5f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q5F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5f OCA], [https://pdbe.org/3q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q5f RCSB], [https://www.ebi.ac.uk/pdbsum/3q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q5f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLYA_SALTY SLYA_SALTY] Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.<ref>PMID:8544813</ref> <ref>PMID:9284144</ref>  


==About this Structure==
==See Also==
[[3q5f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5F OCA].
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021550983</ref><references group="xtra"/><references/>
__TOC__
[[Category: Salmonella enterica]]
</StructureSection>
[[Category: Dolan, K T.]]
[[Category: Large Structures]]
[[Category: Duguid, E M.]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Marr/slya protein family]]
[[Category: Dolan KT]]
[[Category: Protein-dna complex]]
[[Category: Duguid EM]]
[[Category: Transcription-dna complex]]
[[Category: Transcriptonal regulator]]
[[Category: Winged helix-turn-helix]]

Latest revision as of 13:45, 21 February 2024

Crystal structure of the Salmonella transcriptional regulator SlyA in complex with DNACrystal structure of the Salmonella transcriptional regulator SlyA in complex with DNA

Structural highlights

3q5f is a 4 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.96Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SLYA_SALTY Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.[1] [2]

See Also

References

  1. ↑ Ludwig A, Tengel C, Bauer S, Bubert A, Benz R, Mollenkopf HJ, Goebel W. SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli. Mol Gen Genet. 1995 Dec 15;249(5):474-86. PMID:8544813
  2. ↑ Buchmeier N, Bossie S, Chen CY, Fang FC, Guiney DG, Libby SJ. SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages. Infect Immun. 1997 Sep;65(9):3725-30. PMID:9284144

3q5f, resolution 2.96Å

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