3j16: Difference between revisions
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==Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners== | |||
<SX load='3j16' size='340' side='right' viewer='molstar' caption='[[3j16]], [[Resolution|resolution]] 7.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3j16]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J16 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j16 OCA], [https://pdbe.org/3j16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j16 RCSB], [https://www.ebi.ac.uk/pdbsum/3j16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j16 ProSAT]</span></td></tr> | ||
[[3j16]] is a | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST] Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.<ref>PMID:16554824</ref> <ref>PMID:17889667</ref> <ref>PMID:18180287</ref> | |||
==See Also== | ==See Also== | ||
*[[Ribosomal protein | *[[Ribosomal protein S6|Ribosomal protein S6]] | ||
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]] | |||
== | == References == | ||
< | <references/> | ||
__TOC__ | |||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Anger | [[Category: Anger AM]] | ||
[[Category: Armache | [[Category: Armache J-P]] | ||
[[Category: Becker | [[Category: Becker T]] | ||
[[Category: Beckmann | [[Category: Beckmann R]] | ||
[[Category: Berninghausen | [[Category: Berninghausen O]] | ||
[[Category: Daberkow | [[Category: Daberkow I]] | ||
[[Category: Franckenberg | [[Category: Franckenberg S]] | ||
[[Category: Green | [[Category: Green R]] | ||
[[Category: Hopfner | [[Category: Hopfner K-P]] | ||
[[Category: Karcher | [[Category: Karcher A]] | ||
[[Category: Shoemaker | [[Category: Shoemaker CJ]] | ||
[[Category: Sieber | [[Category: Sieber H]] | ||
[[Category: Thomm | [[Category: Thomm M]] | ||
[[Category: Ungewickell | [[Category: Ungewickell C]] | ||
[[Category: Wickles | [[Category: Wickles S]] | ||
Latest revision as of 13:09, 21 February 2024
Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partnersModels of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners
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