2i39: Difference between revisions

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[[Image:2i39.gif|left|200px]]


{{Structure
==Crystal structure of Vaccinia virus N1L protein==
|PDB= 2i39 |SIZE=350|CAPTION= <scene name='initialview01'>2i39</scene>, resolution 2.20&Aring;
<StructureSection load='2i39' size='340' side='right'caption='[[2i39]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
<table><tr><td colspan='2'>[[2i39]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I39 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= N1L (VACWR028) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i39 OCA], [https://pdbe.org/2i39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i39 RCSB], [https://www.ebi.ac.uk/pdbsum/2i39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i39 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i39 OCA], [http://www.ebi.ac.uk/pdbsum/2i39 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i39 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q49PX0_9POXV Q49PX0_9POXV]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i39_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i39 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Vaccinia virus N1L protein'''
==See Also==
 
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
[[Category: Large Structures]]
 
==About this Structure==
2I39 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA].
 
==Reference==
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17123957 17123957]
[[Category: Single protein]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
[[Category: Aleshin, A E.]]
[[Category: Aleshin AE]]
[[Category: Aoyagi, M.]]
[[Category: Aoyagi M]]
[[Category: Liddington, R C.]]
[[Category: Liddington RC]]
[[Category: Stec, B.]]
[[Category: Stec B]]
[[Category: all alpha]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:39:05 2008''

Latest revision as of 12:01, 21 February 2024

Crystal structure of Vaccinia virus N1L proteinCrystal structure of Vaccinia virus N1L protein

Structural highlights

2i39 is a 6 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q49PX0_9POXV

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2i39, resolution 2.20Å

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