1zv1: Difference between revisions

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[[Image:1zv1.png|left|200px]]


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==Crystal structure of the dimerization domain of doublesex protein from D. melanogaster==
The line below this paragraph, containing "STRUCTURE_1zv1", creates the "Structure Box" on the page.
<StructureSection load='1zv1' size='340' side='right'caption='[[1zv1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1zv1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZV1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv1 OCA], [https://pdbe.org/1zv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zv1 ProSAT]</span></td></tr>
{{STRUCTURE_1zv1|  PDB=1zv1  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the dimerization domain of doublesex protein from D. melanogaster===
[https://www.uniprot.org/uniprot/DSX_DROME DSX_DROME] Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.<ref>PMID:12435630</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zv1 ConSurf].
1ZV1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV1 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:16049008</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Bayrer, J R.]]
[[Category: Large Structures]]
[[Category: Li, B.]]
[[Category: Bayrer JR]]
[[Category: Phillips, N B.]]
[[Category: Li B]]
[[Category: Wan, Z.]]
[[Category: Phillips NB]]
[[Category: Weiss, M A.]]
[[Category: Wan Z]]
[[Category: Dimerization]]
[[Category: Weiss MA]]
[[Category: Doublesex]]
[[Category: Sex determination]]
[[Category: Transcription factor]]
[[Category: Uba domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:04:02 2009''

Latest revision as of 12:06, 14 February 2024

Crystal structure of the dimerization domain of doublesex protein from D. melanogasterCrystal structure of the dimerization domain of doublesex protein from D. melanogaster

Structural highlights

1zv1 is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DSX_DROME Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Dauwalder B, Tsujimoto S, Moss J, Mattox W. The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev. 2002 Nov 15;16(22):2879-92. PMID:12435630 doi:http://dx.doi.org/10.1101/gad.1010302

1zv1, resolution 1.60Å

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