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[[Image:1z3a.gif|left|200px]]<br /><applet load="1z3a" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1z3a, resolution 2.03&Aring;" />
'''Crystal structure of tRNA adenosine deaminase TadA from Escherichia coli'''<br />


==About this Structure==
==Crystal structure of tRNA adenosine deaminase TadA from Escherichia coli==
1Z3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3A OCA].  
<StructureSection load='1z3a' size='340' side='right'caption='[[1z3a]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1z3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3a OCA], [https://pdbe.org/1z3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3a RCSB], [https://www.ebi.ac.uk/pdbsum/1z3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3a ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1z3a TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TADA_ECOLI TADA_ECOLI] Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes E.coli resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability.<ref>PMID:12110595</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3a ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Almo, S C.]]
[[Category: Almo SC]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Kim, J.]]
[[Category: Kim J]]
[[Category: Lisbin, M.]]
[[Category: Lisbin M]]
[[Category: Malashkevich, V N.]]
[[Category: Malashkevich V]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: ZN]]
[[Category: dimer]]
[[Category: metalloenzyme]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]
[[Category: trna adenosine deaminase]]
[[Category: zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:42 2008''

Latest revision as of 12:02, 14 February 2024

Crystal structure of tRNA adenosine deaminase TadA from Escherichia coliCrystal structure of tRNA adenosine deaminase TadA from Escherichia coli

Structural highlights

1z3a is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

TADA_ECOLI Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes E.coli resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Wolf J, Gerber AP, Keller W. tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J. 2002 Jul 15;21(14):3841-51. PMID:12110595 doi:http://dx.doi.org/10.1093/emboj/cdf362

1z3a, resolution 2.03Å

Drag the structure with the mouse to rotate

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