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[[Image:1z0z.png|left|200px]]


{{STRUCTURE_1z0z| PDB=1z0z | SCENE= }}
==Crystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with NAD==
<StructureSection load='1z0z' size='340' side='right'caption='[[1z0z]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1z0z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0z OCA], [https://pdbe.org/1z0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0z RCSB], [https://www.ebi.ac.uk/pdbsum/1z0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0z ProSAT], [https://www.topsan.org/Proteins/BSGC/1z0z TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADK_ARCFU NADK_ARCFU] Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.<ref>PMID:16242716</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0z ConSurf].
<div style="clear:both"></div>


===Crystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with NAD===
==See Also==
 
*[[NAD kinase|NAD kinase]]
{{ABSTRACT_PUBMED_16242716}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1z0z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0Z OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:016242716</ref><references group="xtra"/>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Adams, P D.]]
[[Category: Large Structures]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Adams PD]]
[[Category: Kim, R.]]
[[Category: Kim R]]
[[Category: Kim, S H.]]
[[Category: Kim SH]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: Lou, Y.]]
[[Category: Lou Y]]
[[Category: Yokota, H.]]
[[Category: Yokota H]]
[[Category: Berkeley structural genomics center]]
[[Category: Bsgc]]
[[Category: Nad]]
[[Category: Nad kinase]]
[[Category: Nadp]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 12:01, 14 February 2024

Crystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with NADCrystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with NAD

Structural highlights

1z0z is a 4 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.85Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NADK_ARCFU Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005 Nov 25;354(2):289-303. Epub 2005 Sep 30. PMID:16242716 doi:10.1016/j.jmb.2005.09.026

1z0z, resolution 2.85Å

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