1rpu: Difference between revisions

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-{{STRUCTURE_1rpu|  PDB=1rpu  |  SCENE=  }}
-===Crystal Structure of CIRV p19 bound to siRNA===
-{{ABSTRACT_PUBMED_14697199}}
-==About this Structure==
+==Crystal Structure of CIRV p19 bound to siRNA==
-[[1rpu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Carnation_italian_ringspot_virus Carnation italian ringspot virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPU OCA].
+<StructureSection load='1rpu' size='340' side='right'caption='[[1rpu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1rpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Carnation_Italian_ringspot_virus Carnation Italian ringspot virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpu OCA], [https://pdbe.org/1rpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpu RCSB], [https://www.ebi.ac.uk/pdbsum/1rpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P19_CIRV P19_CIRV] Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.<ref>PMID:14697199</ref> <ref>PMID:19254536</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpu_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rpu ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Alignment of 1rpu vs 1r9f|Alignment of 1rpu vs 1r9f]]
+*[[Flock house virus protein B2|Flock house virus protein B2]]
-*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
 *[[P19|P19]]
-*[[RNA Interference|RNA Interference]]
+*[[RNA silencing suppressor|RNA silencing suppressor]]
 *[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
 *[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
-*[[User:Wayne Decatur/Chem791A Work Session|User:Wayne Decatur/Chem791A Work Session]]
+== References ==
-*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]]
+<references/>
-*[[User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing|User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing]]
+__TOC__
-*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]]
+</StructureSection>
-*[[User:Wayne Decatur/Teaching Proteopedia|User:Wayne Decatur/Teaching Proteopedia]]
+[[Category: Carnation Italian ringspot virus]]
-*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
+[[Category: Large Structures]]
+[[Category: Burgyan J]]
-==Reference==
+[[Category: Hall TMT]]
-<ref group="xtra">PMID:014697199</ref><references group="xtra"/>
+[[Category: Szittya G]]
-[[Category: Carnation italian ringspot virus]]
+[[Category: Vargason JM]]
-[[Category: Burgyan, J.]]
-[[Category: Hall, T M.T.]]
-[[Category: Szittya, G.]]
-[[Category: Vargason, J M.]]
-[[Category: Protein-rna complex]]
-[[Category: Rna binding protein-rna complex]]
-[[Category: Rna double helix]]
-[[Category: Rna length recognition]]
-[[Category: Rnai]]