1rku: Difference between revisions

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[[Image:1rku.png|left|200px]]


{{STRUCTURE_1rku|  PDB=1rku  |  SCENE=  }}
==Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa==
 
<StructureSection load='1rku' size='340' side='right'caption='[[1rku]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
===Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1rku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RKU FirstGlance]. <br>
{{ABSTRACT_PUBMED_14699121}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rku OCA], [https://pdbe.org/1rku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rku RCSB], [https://www.ebi.ac.uk/pdbsum/1rku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rku ProSAT]</span></td></tr>
[[1rku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RKU OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/THRH_PSEAE THRH_PSEAE] Phosphoserine phosphatase that mediates dephosphorylation of phosphoserine in the serine biosynthesis pathway. Also able to dephosphorylate other substrates such as phospho-L(or D)-threonine, with lower activity. Shows phosphoserine:homoserine phosphotransferase activity by transferring the phosphoryl group to homoserine using phosphoserine as the phosphoryl group donor.<ref>PMID:10220164</ref> <ref>PMID:14699121</ref>
<ref group="xtra">PMID:014699121</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Pseudomonas aeruginosa pao1]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Huynh, T.]]
Check<jmol>
[[Category: Karthikeyan, S.]]
  <jmolCheckbox>
[[Category: Phillips, M A.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/1rku_consurf.spt"</scriptWhenChecked>
[[Category: Singh, S K.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Subramanian, K.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Yang, K.]]
  </jmolCheckbox>
[[Category: Zhang, H.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rku ConSurf].
[[Category: Zhang, X.]]
<div style="clear:both"></div>
[[Category: Phosphoserine phosphatase]]
== References ==
[[Category: Phosphoserine phosphoryl donor]]
<references/>
[[Category: Phosphoserine:homoserine phosphotransferase]]
__TOC__
[[Category: Thrh]]
</StructureSection>
[[Category: Transferase]]
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Huynh T]]
[[Category: Karthikeyan S]]
[[Category: Phillips MA]]
[[Category: Singh SK]]
[[Category: Subramanian K]]
[[Category: Yang K]]
[[Category: Zhang H]]
[[Category: Zhang X]]

Latest revision as of 11:23, 14 February 2024

Crystal Structure of ThrH gene product of Pseudomonas AeruginosaCrystal Structure of ThrH gene product of Pseudomonas Aeruginosa

Structural highlights

1rku is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.47Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THRH_PSEAE Phosphoserine phosphatase that mediates dephosphorylation of phosphoserine in the serine biosynthesis pathway. Also able to dephosphorylate other substrates such as phospho-L(or D)-threonine, with lower activity. Shows phosphoserine:homoserine phosphotransferase activity by transferring the phosphoryl group to homoserine using phosphoserine as the phosphoryl group donor.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Patte JC, Clepet C, Bally M, Borne F, Mejean V, Foglino M. ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa. Microbiology. 1999 Apr;145 ( Pt 4):845-53. PMID:10220164
  2. ↑ Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H. The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. J Biol Chem. 2004 Mar 26;279(13):13166-73. Epub 2003 Dec 29. PMID:14699121 doi:http://dx.doi.org/10.1074/jbc.M311393200

1rku, resolution 1.47Å

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