1rku

Crystal Structure of ThrH gene product of Pseudomonas AeruginosaCrystal Structure of ThrH gene product of Pseudomonas Aeruginosa

Structural highlights

1rku is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.47Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THRH_PSEAE Phosphoserine phosphatase that mediates dephosphorylation of phosphoserine in the serine biosynthesis pathway. Also able to dephosphorylate other substrates such as phospho-L(or D)-threonine, with lower activity. Shows phosphoserine:homoserine phosphotransferase activity by transferring the phosphoryl group to homoserine using phosphoserine as the phosphoryl group donor.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Patte JC, Clepet C, Bally M, Borne F, Mejean V, Foglino M. ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa. Microbiology. 1999 Apr;145 ( Pt 4):845-53. PMID:10220164
↑ Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H. The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. J Biol Chem. 2004 Mar 26;279(13):13166-73. Epub 2003 Dec 29. PMID:14699121 doi:http://dx.doi.org/10.1074/jbc.M311393200

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Patte JC, Clepet C, Bally M, Borne F, Mejean V, Foglino M. ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa. Microbiology. 1999 Apr;145 ( Pt 4):845-53. PMID:10220164

[2] Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H. The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. J Biol Chem. 2004 Mar 26;279(13):13166-73. Epub 2003 Dec 29. PMID:14699121 doi:http://dx.doi.org/10.1074/jbc.M311393200

[1]

[2]

1rku

Crystal Structure of ThrH gene product of Pseudomonas AeruginosaCrystal Structure of ThrH gene product of Pseudomonas Aeruginosa

Structural highlights

Function

Evolutionary Conservation

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

1rku

Crystal Structure of ThrH gene product of Pseudomonas AeruginosaCrystal Structure of ThrH gene product of Pseudomonas Aeruginosa

Structural highlights

Function

Evolutionary Conservation

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search