1nw1: Difference between revisions

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-[[Image:1nw1.png|left|200px]]
-{{STRUCTURE_1nw1|  PDB=1nw1  |  SCENE=  }}
+==Crystal Structure of Choline Kinase==
+<StructureSection load='1nw1' size='340' side='right'caption='[[1nw1]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-===Crystal Structure of Choline Kinase===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1nw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW1 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12791258}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [https://pdbe.org/1nw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw1 ProSAT]</span></td></tr>
-[[1nw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW1 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CKA2_CAEEL CKA2_CAEEL] Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.<ref>PMID:12758145</ref> <ref>PMID:14960577</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw1 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Hemoglobin|Hemoglobin]]
+*[[Choline kinase 3D structures|Choline kinase 3D structures]]
+*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:012791258</ref><ref group="xtra">PMID:015258570</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Caenorhabditis elegans]]
-[[Category: Choline kinase]]
+[[Category: Large Structures]]
-[[Category: Gee, P.]]
+[[Category: Gee P]]
-[[Category: Kent, C.]]
+[[Category: Kent C]]
-[[Category: Peisach, D.]]
+[[Category: Peisach D]]
-[[Category: Xu, Z.]]
+[[Category: Xu Z]]
-[[Category: Choline kinase]]
-[[Category: Phospholipid synthesis]]
-[[Category: Protein kinase fold]]
-[[Category: Transferase]]