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[[Image:1nj2.png|left|200px]]


{{STRUCTURE_1nj2|  PDB=1nj2  |  SCENE=  }}
==Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus==
 
<StructureSection load='1nj2' size='340' side='right'caption='[[1nj2]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
===Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1nj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NJ2 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12578991}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nj2 OCA], [https://pdbe.org/1nj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nj2 RCSB], [https://www.ebi.ac.uk/pdbsum/1nj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nj2 ProSAT]</span></td></tr>
[[1nj2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ2 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYP_METTH SYP_METTH] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.[HAMAP-Rule:MF_01571]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/1nj2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nj2 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012578991</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
[[Category: Proline--tRNA ligase]]
[[Category: Kamtekar S]]
[[Category: Kamtekar, S.]]
[[Category: Kennedy WD]]
[[Category: Kennedy, W D.]]
[[Category: Soll D]]
[[Category: Soll, D.]]
[[Category: Stathopoulos C]]
[[Category: Stathopoulos, C.]]
[[Category: Steitz TA]]
[[Category: Steitz, T A.]]
[[Category: Wang J]]
[[Category: Wang, J.]]
[[Category: Class-ii trna synthetase]]
[[Category: Ligase]]

Latest revision as of 10:57, 14 February 2024

Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicusCrystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus

Structural highlights

1nj2 is a 1 chain structure with sequence from Methanothermobacter thermautotrophicus str. Delta H. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.11Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYP_METTH Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.[HAMAP-Rule:MF_01571]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1nj2, resolution 3.11Å

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