1n7h: Difference between revisions

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[[Image:1n7h.png|left|200px]]


{{STRUCTURE_1n7h|  PDB=1n7h  |  SCENE=  }}
==Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP==
 
<StructureSection load='1n7h' size='340' side='right'caption='[[1n7h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1n7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N7H FirstGlance]. <br>
{{ABSTRACT_PUBMED_12501186}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7h OCA], [https://pdbe.org/1n7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n7h RCSB], [https://www.ebi.ac.uk/pdbsum/1n7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n7h ProSAT]</span></td></tr>
[[1n7h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7H OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/GMD2_ARATH GMD2_ARATH] Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.<ref>PMID:9050909</ref> <ref>PMID:12805618</ref>
<ref group="xtra">PMID:012501186</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/1n7h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n7h ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: GDP-mannose 4,6-dehydratase]]
[[Category: Large Structures]]
[[Category: Bonin, C P.]]
[[Category: Bonin CP]]
[[Category: Garavito, R M.]]
[[Category: Garavito RM]]
[[Category: Mulichak, A M.]]
[[Category: Mulichak AM]]
[[Category: Reiter, W D.]]
[[Category: Reiter W-D]]
[[Category: Lyase]]
[[Category: Rossmann fold]]
[[Category: Sdr]]
[[Category: Short-chain dehydrogenase/reductase]]

Latest revision as of 10:53, 14 February 2024

Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDPCrystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP

Structural highlights

1n7h is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GMD2_ARATH Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Bonin CP, Potter I, Vanzin GF, Reiter WD. The MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-D-mannose-4,6-dehydratase, catalyzing the first step in the de novo synthesis of GDP-L-fucose. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2085-90. PMID:9050909
  2. ↑ Bonin CP, Freshour G, Hahn MG, Vanzin GF, Reiter WD. The GMD1 and GMD2 genes of Arabidopsis encode isoforms of GDP-D-mannose 4,6-dehydratase with cell type-specific expression patterns. Plant Physiol. 2003 Jun;132(2):883-92. Epub 2003 May 15. PMID:12805618 doi:http://dx.doi.org/10.1104/pp.103.022368

1n7h, resolution 1.80Å

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