1n7h

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Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDPCrystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP

Structural highlights

1n7h is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GMD2_ARATH Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. Bonin CP, Potter I, Vanzin GF, Reiter WD. The MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-D-mannose-4,6-dehydratase, catalyzing the first step in the de novo synthesis of GDP-L-fucose. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2085-90. PMID:9050909
  2. Bonin CP, Freshour G, Hahn MG, Vanzin GF, Reiter WD. The GMD1 and GMD2 genes of Arabidopsis encode isoforms of GDP-D-mannose 4,6-dehydratase with cell type-specific expression patterns. Plant Physiol. 2003 Jun;132(2):883-92. Epub 2003 May 15. PMID:12805618 doi:http://dx.doi.org/10.1104/pp.103.022368

1n7h, resolution 1.80Å

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OCA