1m0u: Difference between revisions

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[[Image:1m0u.png|left|200px]]


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==Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione==
The line below this paragraph, containing "STRUCTURE_1m0u", creates the "Structure Box" on the page.
<StructureSection load='1m0u' size='340' side='right'caption='[[1m0u]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M0U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1m0u| PDB=1m0u |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m0u OCA], [https://pdbe.org/1m0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m0u RCSB], [https://www.ebi.ac.uk/pdbsum/1m0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m0u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSTS1_DROME GSTS1_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).<ref>PMID:12547198</ref> <ref>PMID:1445191</ref> <ref>PMID:22082028</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m0/1m0u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m0u ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
== References ==
<!--
<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 12547198 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12547198}}
 
==About this Structure==
[[1m0u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0U OCA].
 
==Reference==
<ref group="xtra">PMID:012547198</ref><references group="xtra"/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Glutathione transferase]]
[[Category: Large Structures]]
[[Category: Agianian, B.]]
[[Category: Agianian B]]
[[Category: Bullard, B.]]
[[Category: Bullard B]]
[[Category: Gros, P.]]
[[Category: Gros P]]
[[Category: Leonard, K.]]
[[Category: Leonard K]]
[[Category: Schouten, A.]]
[[Category: Schouten A]]
[[Category: Tucker, P A.]]
[[Category: Tucker PA]]
[[Category: Flight muscle protein]]
[[Category: Gst]]
[[Category: Sigma]]
[[Category: Transferase]]

Latest revision as of 10:38, 14 February 2024

Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with GlutathioneCrystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione

Structural highlights

1m0u is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GSTS1_DROME Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Agianian B, Tucker PA, Schouten A, Leonard K, Bullard B, Gros P. Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. J Mol Biol. 2003 Feb 7;326(1):151-65. PMID:12547198
  2. ↑ Beall C, Fyrberg C, Song S, Fyrberg E. Isolation of a Drosophila gene encoding glutathione S-transferase. Biochem Genet. 1992 Oct;30(9-10):515-27. PMID:1445191 doi:10.1007/BF01037590
  3. ↑ Saisawang C, Wongsantichon J, Ketterman AJ. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Biochem J. 2012 Feb 15;442(1):181-90. doi: 10.1042/BJ20111747. PMID:22082028 doi:http://dx.doi.org/10.1042/BJ20111747

1m0u, resolution 1.75Å

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