Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with GlutathioneCrystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione
Structural highlights
1m0u is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GSTS1_DROME Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in the detoxification of metabolites produced during cellular division and morphogenesis (PubMed:1445191, PubMed:12547198).[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Agianian B, Tucker PA, Schouten A, Leonard K, Bullard B, Gros P. Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. J Mol Biol. 2003 Feb 7;326(1):151-65. PMID:12547198
↑Beall C, Fyrberg C, Song S, Fyrberg E. Isolation of a Drosophila gene encoding glutathione S-transferase. Biochem Genet. 1992 Oct;30(9-10):515-27. PMID:1445191 doi:10.1007/BF01037590
↑Saisawang C, Wongsantichon J, Ketterman AJ. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Biochem J. 2012 Feb 15;442(1):181-90. doi: 10.1042/BJ20111747. PMID:22082028 doi:http://dx.doi.org/10.1042/BJ20111747
