1ju4: Difference between revisions

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[[Image:1ju4.png|left|200px]]


{{STRUCTURE_1ju4|  PDB=1ju4  |  SCENE=  }}
==BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT==
 
<StructureSection load='1ju4' size='340' side='right'caption='[[1ju4]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
===BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ju4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._MB1 Rhodococcus sp. MB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11742345}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju4 OCA], [https://pdbe.org/1ju4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju4 ProSAT]</span></td></tr>
[[1ju4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._mb1 Rhodococcus sp. mb1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU4 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1ju4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ju4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cocaine esterase|Cocaine esterase]]
*[[Cocaine esterase|Cocaine esterase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011742345</ref><references group="xtra"/>
__TOC__
[[Category: Rhodococcus sp. mb1]]
</StructureSection>
[[Category: Basran, A.]]
[[Category: Large Structures]]
[[Category: Bruce, N C.]]
[[Category: Rhodococcus sp. MB1]]
[[Category: Larsen, N A.]]
[[Category: Basran A]]
[[Category: Lerner, R A.]]
[[Category: Bruce NC]]
[[Category: Rosser, S J.]]
[[Category: Larsen NA]]
[[Category: Stevens, J.]]
[[Category: Lerner RA]]
[[Category: Turner, J M.]]
[[Category: Rosser SJ]]
[[Category: Wilson, I A.]]
[[Category: Stevens J]]
[[Category: Alpha/beta hydrolase]]
[[Category: Turner JM]]
[[Category: Hydrolase]]
[[Category: Wilson IA]]

Latest revision as of 10:42, 7 February 2024

BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCTBACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT

Structural highlights

1ju4 is a 1 chain structure with sequence from Rhodococcus sp. MB1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.63Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COCE_RHOSM Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Bresler MM, Rosser SJ, Basran A, Bruce NC. Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. Appl Environ Microbiol. 2000 Mar;66(3):904-8. PMID:10698749
  2. ↑ Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol. 2006 Dec;70(6):1885-91. Epub 2006 Sep 12. PMID:16968810 doi:10.1124/mol.106.025999
  3. ↑ Turner JM, Larsen NA, Basran A, Barbas CF 3rd, Bruce NC, Wilson IA, Lerner RA. Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry. 2002 Oct 15;41(41):12297-307. PMID:12369817

1ju4, resolution 1.63Å

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