Cocaine esterase

Function Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. Relevance CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse. Structural highlights CocE contains 3 domains. contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. are involved in substrate recognition. is located at a cleft in the interface of the 3 domains and contains the .

spinqualitylabelsall models Cocaine esterase complex with reaction product benzoic acid (PDB entry 1l7q) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of cocaine esterase3D structures of cocaine esterase

Updated on 02-February-2025

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• Cocaine esterase
  • 3i2j, 3puh - RhCocE – Rhodococcus
    
  • 1l7r, 3pui, 4p08, 9k48 - RhCocE (mutant)
• Cocaine esterase binary complex
  • 1ju3 – RhCocE + transition state inhibitor
    
  • 1ju4 – RhCocE + benzoic acid
    
  • 1l7q, 7f65 - RhCocE (mutant) + benzoic acid
    
  • 3ida, 3i2f, 3i2g, 3i2h, 3i2i - RhCocE (mutant) + DTT derivative
    
  • 3i2k - RhCocE + DTT derivative