1hnn: Difference between revisions

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{{Seed}}
[[Image:1hnn.png|left|200px]]


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==CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)==
The line below this paragraph, containing "STRUCTURE_1hnn", creates the "Structure Box" on the page.
<StructureSection load='1hnn' size='340' side='right'caption='[[1hnn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hnn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HNN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKF:1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-SULFONIC+ACID+AMIDE'>SKF</scene></td></tr>
{{STRUCTURE_1hnn|  PDB=1hnn |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnn OCA], [https://pdbe.org/1hnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hnn RCSB], [https://www.ebi.ac.uk/pdbsum/1hnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hnn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hnn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hnn ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)===
==See Also==
 
*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
 
__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 11591352 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11591352}}
 
==Disease==
Known disease associated with this structure: Hypertension, essential, 145500 (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171190 171190]]
 
==About this Structure==
1HNN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNN OCA].
 
==Reference==
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT., Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL, Structure. 2001 Oct;9(10):977-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11591352 11591352]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Begun J]]
[[Category: Begun, J.]]
[[Category: Caine JM]]
[[Category: Caine, J M.]]
[[Category: Grunewald GL]]
[[Category: Grunewald, G L.]]
[[Category: Martin JL]]
[[Category: Martin, J L.]]
[[Category: McLeish MJ]]
[[Category: McLeish, M J.]]
[[Category: Adrenaline synthesis]]
[[Category: Methyltransferase]]
[[Category: S-adenosyl methionine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:26:27 2008''

Latest revision as of 10:28, 7 February 2024

CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)

Structural highlights

1hnn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PNMT_HUMAN Converts noradrenaline to adrenaline.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1hnn, resolution 2.40Å

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