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==CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT== | |||
<StructureSection load='1ft0' size='340' side='right'caption='[[1ft0]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FT0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft0 OCA], [https://pdbe.org/1ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/1ft0_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ft0 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Derewenda ZS]] | ||
[[Category: | [[Category: Garrard SM]] | ||
[[Category: | [[Category: Longenecker KL]] | ||
[[Category: | [[Category: Sheffield PJ]] | ||
Latest revision as of 10:19, 7 February 2024
CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANTCRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT
Structural highlights
FunctionGDIR1_HUMAN Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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