1f7t: Difference between revisions

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[[Image:1f7t.png|left|200px]]


{{STRUCTURE_1f7t|  PDB=1f7t  |  SCENE=  }}
==HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A==
 
<StructureSection load='1f7t' size='340' side='right'caption='[[1f7t]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1f7t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F7T FirstGlance]. <br>
{{ABSTRACT_PUBMED_10997907}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f7t OCA], [https://pdbe.org/1f7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f7t RCSB], [https://www.ebi.ac.uk/pdbsum/1f7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7t ProSAT]</span></td></tr>
[[1f7t]] is a 6 chain structure of [[Acyl carrier protein synthase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7T OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACPS_BACSU ACPS_BACSU] Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of fatty acid acyl-carrier-protein ACP. Also modifies the D-alanyl carrier protein but fails to recognize PCP and AcpK, an acyl carrier protein of secondary metabolism.<ref>PMID:11489886</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f7t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7t ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
 
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
==Reference==
*[[Proteins from Mycobacterium tuberculosis|Proteins from Mycobacterium tuberculosis]]
<ref group="xtra">PMID:010997907</ref><references group="xtra"/>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Fritz, C C.]]
[[Category: Large Structures]]
[[Category: Hixon, J.]]
[[Category: Fritz CC]]
[[Category: Lin, L.]]
[[Category: Hixon J]]
[[Category: Mathew, R.]]
[[Category: Lin L]]
[[Category: Parris, K D.]]
[[Category: Mathew R]]
[[Category: Seehra, J.]]
[[Category: Parris KD]]
[[Category: Somers, W S.]]
[[Category: Seehra J]]
[[Category: Stahl, M.]]
[[Category: Somers WS]]
[[Category: Tam, A.]]
[[Category: Stahl M]]
[[Category: 9-strand pseudo beta barrel]]
[[Category: Tam A]]
[[Category: Lipid synthesis]]
[[Category: Transferase]]

Latest revision as of 10:11, 7 February 2024

HOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8AHOLO-(ACYL CARRIER PROTEIN) SYNTHASE AT 1.8A

Structural highlights

1f7t is a 6 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACPS_BACSU Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of fatty acid acyl-carrier-protein ACP. Also modifies the D-alanyl carrier protein but fails to recognize PCP and AcpK, an acyl carrier protein of secondary metabolism.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Mootz HD, Finking R, Marahiel MA. 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J Biol Chem. 2001 Oct 5;276(40):37289-98. Epub 2001 Aug 6. PMID:11489886 doi:http://dx.doi.org/10.1074/jbc.M103556200

1f7t, resolution 1.80Å

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