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[[Image:1c1k.png|left|200px]]


{{STRUCTURE_1c1k|  PDB=1c1k  |  SCENE=  }}
==BACTERIOPHAGE T4 GENE 59 HELICASE ASSEMBLY PROTEIN==
 
<StructureSection load='1c1k' size='340' side='right'caption='[[1c1k]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
===BACTERIOPHAGE T4 GENE 59 HELICASE ASSEMBLY PROTEIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1c1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1K FirstGlance]. <br>
{{ABSTRACT_PUBMED_10669611}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IR:IRIDIUM+ION'>IR</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1k OCA], [https://pdbe.org/1c1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1k RCSB], [https://www.ebi.ac.uk/pdbsum/1c1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1k ProSAT]</span></td></tr>
[[1c1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1K OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/HLOAD_BPT4 HLOAD_BPT4] DNA helicase loader protein that participates in viral DNA replication, recombination, and repair (PubMed:10871615). At the fork, required for loading of the replicative helicase onto DNA protected by the ssDNA-binding protein (PubMed:11459967, PubMed:7806533, PubMed:10871615, PubMed:22427673). Coordinates simultaneous synthesis of leading- and lagging-strands (PubMed:11459969).[HAMAP-Rule:MF_04156]<ref>PMID:10871615</ref> <ref>PMID:11459967</ref> <ref>PMID:22427673</ref> <ref>PMID:7806533</ref> <ref>PMID:11459969</ref>
<ref group="xtra">PMID:010669611</ref><ref group="xtra">PMID:014695246</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Enterobacteria phage t4]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Hyde, C C.]]
Check<jmol>
[[Category: Jones, C E.]]
  <jmolCheckbox>
[[Category: Mueser, T C.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1k_consurf.spt"</scriptWhenChecked>
[[Category: Nossal, N G.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Dna binding protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Dna recombination]]
  </jmolCheckbox>
[[Category: Dna replication]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1k ConSurf].
[[Category: Forked dna]]
<div style="clear:both"></div>
[[Category: Helicase assembly]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Hyde CC]]
[[Category: Jones CE]]
[[Category: Mueser TC]]
[[Category: Nossal NG]]

Latest revision as of 09:40, 7 February 2024

BACTERIOPHAGE T4 GENE 59 HELICASE ASSEMBLY PROTEINBACTERIOPHAGE T4 GENE 59 HELICASE ASSEMBLY PROTEIN

Structural highlights

1c1k is a 1 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HLOAD_BPT4 DNA helicase loader protein that participates in viral DNA replication, recombination, and repair (PubMed:10871615). At the fork, required for loading of the replicative helicase onto DNA protected by the ssDNA-binding protein (PubMed:11459967, PubMed:7806533, PubMed:10871615, PubMed:22427673). Coordinates simultaneous synthesis of leading- and lagging-strands (PubMed:11459969).[HAMAP-Rule:MF_04156][1] [2] [3] [4] [5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Jones CE, Mueser TC, Nossal NG. Interaction of the bacteriophage T4 gene 59 helicase loading protein and gene 41 helicase with each other and with fork, flap, and cruciform DNA. J Biol Chem. 2000 Sep 1;275(35):27145-54. PMID:10871615 doi:10.1074/jbc.M003808200
  2. ↑ Bleuit JS, Xu H, Ma Y, Wang T, Liu J, Morrical SW. Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8298-305. PMID:11459967 doi:10.1073/pnas.131007498
  3. ↑ Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA. J Biol Chem. 2012 May 25;287(22):18596-607. PMID:22427673 doi:10.1074/jbc.M111.332080
  4. ↑ Barry J, Alberts B. Purification and characterization of bacteriophage T4 gene 59 protein. A DNA helicase assembly protein involved in DNA replication. J Biol Chem. 1994 Dec 30;269(52):33049-62 PMID:7806533
  5. ↑ Jones CE, Mueser TC, Dudas KC, Kreuzer KN, Nossal NG. Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: a versatile couple with roles in replication and recombination. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8312-8. PMID:11459969 doi:10.1073/pnas.121009398

1c1k, resolution 1.45Å

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