Tumor necrosis factor: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'> | ||
== Function == | == Function == | ||
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]]. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/ | The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>. | ||
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== 3D Structures of tumor necrosis factor == | == 3D Structures of tumor necrosis factor == | ||
[[Tumor necrosis factor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 14:08, 5 February 2024
FunctionTumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells[1]. TNFβ is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase). See also TRAIL and Molecular Playground/TRAIL. RelevanceTNF is studied as both a target and a therapeutic in malignant diseases[2]. Structural highlightsThe biological assembly of human tumor necrosis factor is (PDB entry 2az5). .
3D Structures of tumor necrosis factorTumor necrosis factor 3D structures References
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