2u2f: Difference between revisions

<StructureSection load='2u2f' size='340' side='right'caption='[[2u2f]]' scene=''>

<table><tr><td colspan='2'>[[2u2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2U2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2U2F FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2u2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2u2f OCA], [https://pdbe.org/2u2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2u2f RCSB], [https://www.ebi.ac.uk/pdbsum/2u2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2u2f ProSAT], [https://www.topsan.org/Proteins/RSGI/2u2f TOPSAN]</span></td></tr>

[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>  

[[Category: Homo sapiens]]

[[Category: Green MR]]

[[Category: Ito T]]

[[Category: Muto Y]]

[[Category: Yokoyama S]]