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==Solution structure of the stn_TNFRSF12A_TNFR domain of Tumor necrosis factor receptor superfamily member 12A precursor==
==Solution structure of the stn_TNFRSF12A_TNFR domain of Tumor necrosis factor receptor superfamily member 12A precursor==
<StructureSection load='2eqp' size='340' side='right' caption='[[2eqp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2eqp' size='340' side='right'caption='[[2eqp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EQP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQP FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF12A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eqp OCA], [http://pdbe.org/2eqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eqp RCSB], [http://www.ebi.ac.uk/pdbsum/2eqp PDBsum], [http://www.topsan.org/Proteins/RSGI/2eqp TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eqp OCA], [https://pdbe.org/2eqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eqp RCSB], [https://www.ebi.ac.uk/pdbsum/2eqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eqp ProSAT], [https://www.topsan.org/Proteins/RSGI/2eqp TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNR12_HUMAN TNR12_HUMAN]] Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.<ref>PMID:11728344</ref>
[https://www.uniprot.org/uniprot/TNR12_HUMAN TNR12_HUMAN] Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.<ref>PMID:11728344</ref>  


==See Also==
==See Also==
*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Dang, W]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Dang W]]
[[Category: Kigawa, T]]
[[Category: Inoue M]]
[[Category: Muto, Y]]
[[Category: Kigawa T]]
[[Category: Structural genomic]]
[[Category: Muto Y]]
[[Category: Shirouzu, M]]
[[Category: Shirouzu M]]
[[Category: Terada, T]]
[[Category: Terada T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Cd266 antigen]]
[[Category: Fgf-inducible 14]]
[[Category: Fibroblast growth factor-inducible immediate-early response protein 14]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Stn_tnfrsf12a_tnfr domain]]
[[Category: Transcription]]
[[Category: Tumor necrosis factor receptor superfamily member 12a precursor]]
[[Category: Tweak-receptor]]
[[Category: Tweakr]]

Latest revision as of 19:35, 13 December 2023

Solution structure of the stn_TNFRSF12A_TNFR domain of Tumor necrosis factor receptor superfamily member 12A precursorSolution structure of the stn_TNFRSF12A_TNFR domain of Tumor necrosis factor receptor superfamily member 12A precursor

Structural highlights

2eqp is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

TNR12_HUMAN Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.[1]

See Also

References

  1. ↑ Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001 Nov;15(5):837-46. PMID:11728344
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