2v40: Difference between revisions

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-{{Seed}}
-[[Image:2v40.png|left|200px]]
-<!--
+==Human Adenylosuccinate synthetase isozyme 2 in complex with GDP==
-The line below this paragraph, containing "STRUCTURE_2v40", creates the "Structure Box" on the page.
+<StructureSection load='2v40' size='340' side='right'caption='[[2v40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2v40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V40 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-{{STRUCTURE_2v40|  PDB=2v40  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v40 OCA], [https://pdbe.org/2v40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v40 RCSB], [https://www.ebi.ac.uk/pdbsum/2v40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v40 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PURA2_HUMAN PURA2_HUMAN] Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB:P46664]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v40_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v40 ConSurf].
+<div style="clear:both"></div>
-===HUMAN ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 IN COMPLEX WITH GDP===
+==See Also==
+*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-V40 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V40 OCA].
-[[Category: Adenylosuccinate synthase]]
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Berglund, H.]]
+[[Category: Arrowsmith C]]
-[[Category: Busam, R.]]
+[[Category: Berglund H]]
-[[Category: Collins, R.]]
+[[Category: Busam R]]
-[[Category: Dahlgren, L G.]]
+[[Category: Collins R]]
-[[Category: Edwards, A.]]
+[[Category: Dahlgren LG]]
-[[Category: Flodin, S.]]
+[[Category: Edwards A]]
-[[Category: Flores, A.]]
+[[Category: Flodin S]]
-[[Category: Graslund, S.]]
+[[Category: Flores A]]
-[[Category: Hallberg, B M.]]
+[[Category: Graslund S]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hallberg BM]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Hammarstrom M]]
-[[Category: Johansson, I.]]
+[[Category: Holmberg-Schiavone L]]
-[[Category: Kallas, A.]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T.]]
+[[Category: Kallas A]]
-[[Category: Kotenyova, T.]]
+[[Category: Karlberg T]]
-[[Category: Lehtio, L.]]
+[[Category: Kotenyova T]]
-[[Category: Moche, M.]]
+[[Category: Lehtio L]]
-[[Category: Nordlund, P.]]
+[[Category: Moche M]]
-[[Category: Nyman, T.]]
+[[Category: Nordlund P]]
-[[Category: Ogg, D.]]
+[[Category: Nyman T]]
-[[Category: Persson, C.]]
+[[Category: Ogg D]]
-[[Category: Sagemark, J.]]
+[[Category: Persson C]]
-[[Category: Sgc, Structural Genomics Consortium.]]
+[[Category: Sagemark J]]
-[[Category: Stenmark, P.]]
+[[Category: Stenmark P]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Thorsell, A G.]]
+[[Category: Thorsell AG]]
-[[Category: Tresaugues, L.]]
+[[Category: Tresaugues L]]
-[[Category: Van-Den-Berg, S.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Welin M]]
-[[Category: Welin, M.]]
+[[Category: Van den Berg S]]
-[[Category: Adenylosuccinate synthetase]]
-[[Category: Adss2]]
-[[Category: Gdp]]
-[[Category: Gtp-binding]]
-[[Category: Ligase]]
-[[Category: Magnesium]]
-[[Category: Metal-binding]]
-[[Category: Nucleotide-binding]]
-[[Category: Purine biosynthesis]]
-[[Category: Purine metabolism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:12:50 2009''