2v40: Difference between revisions

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==Human Adenylosuccinate synthetase isozyme 2 in complex with GDP==
==Human Adenylosuccinate synthetase isozyme 2 in complex with GDP==
<StructureSection load='2v40' size='340' side='right' caption='[[2v40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2v40' size='340' side='right'caption='[[2v40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2v40]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V40 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2v40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V40 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v40 OCA], [http://pdbe.org/2v40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v40 RCSB], [http://www.ebi.ac.uk/pdbsum/2v40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v40 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v40 OCA], [https://pdbe.org/2v40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v40 RCSB], [https://www.ebi.ac.uk/pdbsum/2v40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v40 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PURA2_HUMAN PURA2_HUMAN] Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB:P46664]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v40_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v40_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 20: Line 22:


==See Also==
==See Also==
*[[Adenylosuccinate Synthetase|Adenylosuccinate Synthetase]]
*[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenylosuccinate synthase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith C]]
[[Category: Berg, S van den]]
[[Category: Berglund H]]
[[Category: Berglund, H]]
[[Category: Busam R]]
[[Category: Busam, R]]
[[Category: Collins R]]
[[Category: Collins, R]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Flodin S]]
[[Category: Flodin, S]]
[[Category: Flores A]]
[[Category: Flores, A]]
[[Category: Graslund S]]
[[Category: Graslund, S]]
[[Category: Hallberg BM]]
[[Category: Hallberg, B M]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M]]
[[Category: Holmberg-Schiavone L]]
[[Category: Holmberg-Schiavone, L]]
[[Category: Johansson I]]
[[Category: Johansson, I]]
[[Category: Kallas A]]
[[Category: Kallas, A]]
[[Category: Karlberg T]]
[[Category: Karlberg, T]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T]]
[[Category: Lehtio L]]
[[Category: Lehtio, L]]
[[Category: Moche M]]
[[Category: Moche, M]]
[[Category: Nordlund P]]
[[Category: Nordlund, P]]
[[Category: Nyman T]]
[[Category: Nyman, T]]
[[Category: Ogg D]]
[[Category: Ogg, D]]
[[Category: Persson C]]
[[Category: Persson, C]]
[[Category: Sagemark J]]
[[Category: Structural genomic]]
[[Category: Stenmark P]]
[[Category: Sagemark, J]]
[[Category: Sundstrom M]]
[[Category: Stenmark, P]]
[[Category: Thorsell AG]]
[[Category: Sundstrom, M]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G]]
[[Category: Weigelt J]]
[[Category: Tresaugues, L]]
[[Category: Welin M]]
[[Category: Weigelt, J]]
[[Category: Van den Berg S]]
[[Category: Welin, M]]
[[Category: Adenylosuccinate synthetase]]
[[Category: Adss2]]
[[Category: Gdp]]
[[Category: Gtp-binding]]
[[Category: Ligase]]
[[Category: Magnesium]]
[[Category: Metal- binding]]
[[Category: Nucleotide-binding]]
[[Category: Purine biosynthesis]]
[[Category: Purine metabolism]]

Latest revision as of 18:05, 13 December 2023

Human Adenylosuccinate synthetase isozyme 2 in complex with GDPHuman Adenylosuccinate synthetase isozyme 2 in complex with GDP

Structural highlights

2v40 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PURA2_HUMAN Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB:P46664]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2v40, resolution 1.90Å

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OCA
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