2v40: Difference between revisions
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==Human Adenylosuccinate synthetase isozyme 2 in complex with GDP== | |||
<StructureSection load='2v40' size='340' side='right'caption='[[2v40]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V40 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
[[2v40]] is a 1 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v40 OCA], [https://pdbe.org/2v40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v40 RCSB], [https://www.ebi.ac.uk/pdbsum/2v40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v40 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PURA2_HUMAN PURA2_HUMAN] Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB:P46664] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v40_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v40 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Adenylosuccinate | *[[Adenylosuccinate synthetase 3D structures|Adenylosuccinate synthetase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Berglund | [[Category: Arrowsmith C]] | ||
[[Category: Busam | [[Category: Berglund H]] | ||
[[Category: Collins | [[Category: Busam R]] | ||
[[Category: Dahlgren | [[Category: Collins R]] | ||
[[Category: Edwards | [[Category: Dahlgren LG]] | ||
[[Category: Flodin | [[Category: Edwards A]] | ||
[[Category: Flores | [[Category: Flodin S]] | ||
[[Category: Graslund | [[Category: Flores A]] | ||
[[Category: Hallberg | [[Category: Graslund S]] | ||
[[Category: Hammarstrom | [[Category: Hallberg BM]] | ||
[[Category: Holmberg-Schiavone | [[Category: Hammarstrom M]] | ||
[[Category: Johansson | [[Category: Holmberg-Schiavone L]] | ||
[[Category: Kallas | [[Category: Johansson I]] | ||
[[Category: Karlberg | [[Category: Kallas A]] | ||
[[Category: Kotenyova | [[Category: Karlberg T]] | ||
[[Category: Lehtio | [[Category: Kotenyova T]] | ||
[[Category: Moche | [[Category: Lehtio L]] | ||
[[Category: Nordlund | [[Category: Moche M]] | ||
[[Category: Nyman | [[Category: Nordlund P]] | ||
[[Category: Ogg | [[Category: Nyman T]] | ||
[[Category: Persson | [[Category: Ogg D]] | ||
[[Category: Sagemark | [[Category: Persson C]] | ||
[[Category: Sagemark J]] | |||
[[Category: Stenmark | [[Category: Stenmark P]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Thorsell | [[Category: Thorsell AG]] | ||
[[Category: Tresaugues | [[Category: Tresaugues L]] | ||
[[Category: Weigelt J]] | |||
[[Category: Weigelt | [[Category: Welin M]] | ||
[[Category: Welin | [[Category: Van den Berg S]] | ||
[[Category: | |||
Latest revision as of 18:05, 13 December 2023
Human Adenylosuccinate synthetase isozyme 2 in complex with GDPHuman Adenylosuccinate synthetase isozyme 2 in complex with GDP
Structural highlights
FunctionPURA2_HUMAN Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.[UniProtKB:P46664] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Large Structures
- Arrowsmith C
- Berglund H
- Busam R
- Collins R
- Dahlgren LG
- Edwards A
- Flodin S
- Flores A
- Graslund S
- Hallberg BM
- Hammarstrom M
- Holmberg-Schiavone L
- Johansson I
- Kallas A
- Karlberg T
- Kotenyova T
- Lehtio L
- Moche M
- Nordlund P
- Nyman T
- Ogg D
- Persson C
- Sagemark J
- Stenmark P
- Sundstrom M
- Thorsell AG
- Tresaugues L
- Weigelt J
- Welin M
- Van den Berg S