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==THREE DIMENSIONAL STRUCTURE OF BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE FROM MYCOBACTERIUM TUBERCULOSIS==
 
<StructureSection load='2c2x' size='340' side='right' caption='[[2c2x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
==Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosis==
<StructureSection load='2c2x' size='340' side='right'caption='[[2c2x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c2x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2X FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c2y|2c2y]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB], [http://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [http://www.topsan.org/Proteins/TBSGC/2c2x TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [https://pdbe.org/2c2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB], [https://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2x ProSAT], [https://www.topsan.org/Proteins/TBSGC/2c2x TOPSAN]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOLD_MYCTU FOLD_MYCTU] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2x_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2x_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2x ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Large Structures]]
[[Category: Javid-Majd, F.]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Sacchettini, J C.]]
[[Category: Javid-Majd F]]
[[Category: Tbsgc, Tb Structural Genomics Consortium.]]
[[Category: Sacchettini JC]]
[[Category: Cyclohydrolase]]
[[Category: Hydrolase]]
[[Category: Methylenetetrahydrofolate dehydrogenase]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Tetrahydrofolate]]

Latest revision as of 17:03, 13 December 2023

Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosisThree dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosis

Structural highlights

2c2x is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

FOLD_MYCTU Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2c2x, resolution 2.00Å

Drag the structure with the mouse to rotate

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OCA
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