Talin: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(7 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
 
[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.


[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
</StructureSection>
== 3D Structures of Talin ==
== 3D Structures of Talin ==
[[Talin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
* Talin subdomains
**[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
**[[2kma]] – mTal F0F1 – NMR<br />
**[[2kc1]] - mTal F0 – NMR<br />
**[[2kc2]] - mTal F1 – NMR<br />
**[[2hrj]] - cTal F2 – NMR <br />
**[[1mix]] – cTal F2F3<br />
**[[4f7g]] - mTal F2F3 + rod segment domain<br />
**[[2kgx]] – mTal F3+mTal fragment – NMR<br />
**[[3ivf]] – mTal FERM domain<br />
**[[2l7n]] – mTal B – NMR<br />
**[[2l10]] – mTal C - NMR<br />
**[[2lqg]] - mTal R4 helix – NMR<br />
**[[4w8p]] - mTal R7-8 + RIAM <br />
**[[2mwn]] – hTal1 + RIAM – human - NMR<br />
* Talin integrin-binding sites
**[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
**[[3g9w]] – mTal2 F2F3+integrin tail<br />
**[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
**[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
**[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
* Talin vinculin-binding sites
**[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
**[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
**[[1u6h]] - cTal VBS2+ vinculin head<br />
**[[1t01]] - cTal VBS1+ vinculin head<br />
**[[1syq]] - hTal VBS1+ vinculin head <br />
**[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br />
**[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
**[[4dj9]] – hTal VBS50 + vinculin head
*Talin phosphatidylinositol phosphate kinase binding sites
**[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
**[[2g35]] - mTal F3+PIP kinase peptide – NMR
*Talin layilin-binding sites
**[[2k00]] - cTal F3+layilin fragment – NMR
}}
== References ==
== References ==
<references/>
<references/>
</StructureSection>
[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 12:58, 12 December 2023


Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin3D Structures of Talin

Talin 3D structures

ReferencesReferences

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

</StructureSection>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Talin&oldid=3978558"