Talin: Difference between revisions

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[[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
<StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'>
{{STRUCTURE_2x0c|  PDB=2x0c  | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
[[Talin]] is involved in cell-cell contacts.  It links integrins to actin.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3.  The F3 subdomains interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
 
{{TOC limit|limit=2}}


[[Talin]] is involved in cell-cell contacts.  It links integrins to actin<ref>PMID:19416068</ref>.  It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3.  The F3 subdomain interacts with integrin.  Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
</StructureSection>
== 3D Structures of Talin ==
== 3D Structures of Talin ==
[[Talin 3D structures]]


''Updated December 2011''
== References ==
 
<references/>
=== Talin subdomains ===
</StructureSection>
 
[[Category: Topic Page]]
[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
[[2kma]] – mTal F0F1 – NMR<br />
[[2kc1]] - mTal F0 – NMR<br />
[[2kc2]] - mTal F1 – NMR<br />
[[2hrj]] - cTal F2 – NMR <br />
[[1mix]] – cTal F2F3<br />
[[2kgx]] – mTal F3+mTal fragment – NMR<br />
[[3ivf]] – mTal FERM domain<br />
[[2l10]] – mTal C - NMR
 
=== Talin integrin-binding sites ===
 
[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
[[3g9w]] – mTal F2F3+integrin tail<br />
[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
 
=== Talin vinculin-binding sites ===
 
[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
[[1u6h]] - cTal VBS2+ vinculin head<br />
[[1t01]] - cTal VBS1+ vinculin head<br />
[[1syq]] - hTal VBS1+ vinculin head – human<br />
[[1rkc]] - hTal VBS3+ vinculin head<br />
[[1u89]] - mTal VBS2 – NMR<br />
 
 
 
=== Talin PIP kinase binding sites ===
 
[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
[[2g35]] - mTal F3+PIP kinase peptide – NMR
 
 
=== Layilin binding sites ===
 
[[2k00]] - cTal F3+layilin fragment – NMR
 
[[Category:Topic Page]]

Latest revision as of 12:58, 12 December 2023


Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

Talin rod domain residues 1359-1659 (PDB code 2x0c)

Drag the structure with the mouse to rotate

3D Structures of Talin3D Structures of Talin

Talin 3D structures

ReferencesReferences

  1. ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

</StructureSection>

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Alexander Berchansky, Michal Harel, Joel L. Sussman
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