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| [[Image:2x0c.png|left|200px|thumb|Crystal Structure of Talin [[2x0c]]]]
| | <StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'> |
| {{STRUCTURE_2x0c| PDB=2x0c | SIZE=300| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
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| [[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, ''i.e.'' the crystal structure of mouse Talin rod ([[2x0c]]).
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| | [[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. |
| | </StructureSection> |
| == 3D Structures of Talin == | | == 3D Structures of Talin == |
| | [[Talin 3D structures]] |
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| === Talin subdomains === | | == References == |
| | | <references/> |
| [[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
| | </StructureSection> |
| [[2kma]] – mTal F0F1 – NMR<br />
| | [[Category: Topic Page]] |
| [[2kc1]] - mTal F0 – NMR<br />
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| [[2kc2]] - mTal F1 – NMR<br />
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| [[2hrj]] - cTal F2 – NMR <br />
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| [[1mix]] – cTal F2F3<br />
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| [[2kgx]] – mTal F3+mTal fragment – NMR<br />
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| [[3ivf]] – mTal FERM domain
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| === Integrin binding sites ===
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| [[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
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| [[3g9w]] – mTal F2F3+integrin tail<br />
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| [[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
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| [[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
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| [[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
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| === Vinculin binding sites ===
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| [[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
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| [[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
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| [[1u6h]] - cTal VBS2+ vinculin head<br />
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| [[1t01]] - cTal VBS1+ vinculin head<br />
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| [[1syq]] - hTal VBS1+ vinculin head – human<br />
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| [[1rkc]] - hTal VBS3+ vinculin head<br />
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| [[1u89]] - mTal VBS2 – NMR<br />
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| === PIP kinase binding sites ===
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| [[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
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| [[2g35]] - mTal F3+PIP kinase peptide – NMR
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| === Layilin binding sites ===
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| [[2k00]] - cTal F3+layilin fragment – NMR
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| [[Category:Topic Page]] | |