Syntaxin-binding protein: Difference between revisions
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<StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide ( | <StructureSection load='3puj' size='340' side='right' caption='Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code [[3puj]])' scene='80/803232/Cv/1'> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='80/803232/Cv/ | <scene name='80/803232/Cv/4'>Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1</scene> which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions<ref name="stxbp"/>. | ||
</StructureSection> | </StructureSection> | ||
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*Syntaxin-binding protein 1 or Munc18-1 | *Syntaxin-binding protein 1 or Munc18-1 | ||
**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + | **[[6lpc]] – rSTXBP1 (mutant) – rat<br /> | ||
**[[4jeh]], [[4jeu]], [[3c98]] – rSTXBP1 + STX-1a<br /> | |||
**[[7udb]], [[7udc]] – rSTXBP1 + synaptobrevin-2 + STX-1a – Cryo EM<br /> | |||
**[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br /> | **[[3puj]] – rSTXBP1 + syntaxin 4 peptide <br /> | ||
**[[7xsj]] – rSTXBP1 + Syntaxin 1a N-terminal+SNARE motif + amyloid-beta A4<br /> | |||
*Syntaxin-binding protein 2 or Munc18-2 | *Syntaxin-binding protein 2 or Munc18-2 | ||
Latest revision as of 14:13, 11 December 2023
FunctionSyntaxin-binding proteins (STXBP) are involved in the regulation of synaptic vesicle docking and fusion. STXBP1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding Syntaxin-1 and as a fusion protein that binds SNARE complexes in a Syntaxin-1 N-peptide-dependent manner[1]. STXBP2 binds SNARE proteins. Structural highlightswhich forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions[1].
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3D structures of syntaxin-binding protein3D structures of syntaxin-binding protein
Updated on 11-December-2023
ReferencesReferences
- ↑ 1.0 1.1 Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2010 Dec 30. PMID:21193638 doi:10.1073/pnas.0914906108