7f77: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 7f77 is ON HOLD  until Paper Publication
+==Crystal structure of glutamate dehydrogenase 3 from Candida albicans==
+<StructureSection load='7f77' size='340' side='right'caption='[[7f77]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7f77]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F77 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.086&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f77 OCA], [https://pdbe.org/7f77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f77 RCSB], [https://www.ebi.ac.uk/pdbsum/7f77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f77 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A1D8PMH8_CANAL A0A1D8PMH8_CANAL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Glutamate dehydrogenase 3 from Candida albicans (CaGdh3) catalyzes the reversible oxidative deamination of l-glutamate, playing an important role in the yeast-to-hyphal transition of C. albicans. Here we report the crystal structures of CaGdh3 and its complex with alpha-ketoglutarate and NADPH. CaGdh3 exists as a hexamer, with each subunit containing two domains. The substrate and coenzyme bind in the cleft between the two domains and their binding induces a conformational change in CaGdh3. Our results will help to understand the catalytic mechanism of CaGdh3 and will provide a structural basis for the design of antifungal drugs targeting the CaGdh3 pathway.
-Authors:
+Crystal structure of glutamate dehydrogenase 3 from Candida albicans.,Li N, Wang W, Zeng X, Liu M, Li M, Li C, Wang M Biochem Biophys Res Commun. 2021 Jul 13;570:15-20. doi:, 10.1016/j.bbrc.2021.07.014. PMID:34271431<ref>PMID:34271431</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 7f77" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Glutamate dehydrogenase 3D structures|Glutamate dehydrogenase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Candida albicans SC5314]]
+[[Category: Large Structures]]
+[[Category: Li C]]
+[[Category: Li M]]
+[[Category: Li N]]
+[[Category: Liu M]]
+[[Category: Wang M]]
+[[Category: Wang W]]
+[[Category: Zeng X]]