7eqh: Difference between revisions

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-'''Unreleased structure'''
-The entry 7eqh is ON HOLD
+==Crystal structure of Arabidopsis GUN2/HO1 in complex with heme==
+<StructureSection load='7eqh' size='340' side='right'caption='[[7eqh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7eqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EQH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eqh OCA], [https://pdbe.org/7eqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eqh RCSB], [https://www.ebi.ac.uk/pdbsum/7eqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eqh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMOX1_ARATH HMOX1_ARATH] Key enzyme in the synthesis of the chromophore of the phytochrome family of plant photoreceptors. Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Can form complex with heme, is ferredoxin-dependent and its activity is increased in the presence of ascorbate. Plays a role in salt acclimation signaling. May affect the plastid-to-nucleus signaling pathway by perturbing tetrapyrrole synthesis. The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins.<ref>PMID:10072395</ref> <ref>PMID:10339624</ref> <ref>PMID:11135121</ref> <ref>PMID:11172074</ref> <ref>PMID:12232145</ref> <ref>PMID:12324588</ref> <ref>PMID:12481078</ref> <ref>PMID:16428602</ref> <ref>PMID:19860740</ref> <ref>PMID:20979354</ref> <ref>PMID:21205037</ref> <ref>PMID:7690685</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Arabidopsis thaliana heme oxygenase-1 (AtHO-1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin-related functions in plants. Past biological analyses revealed that AtHO-1 requires ferredoxin-NADP(+) reductase (FNR) and ferredoxin for its enzymatic activity. Here, we characterized the binding and degradation of heme by AtHO-1, and found that ferredoxin is a dispensable component of the reducing system that provides electrons for heme oxidation. Furthermore, we reported the crystal structure of heme-bound AtHO-1, which demonstrates both conserved and previously undescribed features of plant heme oxygenases. Finally, the electron transfer pathway from FNR to AtHO-1 is suggested based on the known structural information.
-Authors:
+Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase-1.,Wang J, Li X, Chang JW, Ye T, Mao Y, Wang X, Liu L FEBS Open Bio. 2022 Sep;12(9):1677-1687. doi: 10.1002/2211-5463.13453. Epub 2022 , Jun 20. PMID:35689519<ref>PMID:35689519</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 7eqh" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Large Structures]]
+[[Category: Li X]]
+[[Category: Liu L]]
+[[Category: Wang J]]