7d1x: Difference between revisions

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New page: '''Unreleased structure''' The entry 7d1x is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 7d1x is ON HOLD
==Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)==
<StructureSection load='7d1x' size='340' side='right'caption='[[7d1x]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7d1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D1X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d1x OCA], [https://pdbe.org/7d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d1x RCSB], [https://www.ebi.ac.uk/pdbsum/7d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d1x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ST2A8_MOUSE ST2A8_MOUSE] Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.<ref>PMID:28442498</ref> <ref>PMID:29685090</ref> <ref>PMID:33872606</ref>


Authors:  
==See Also==
 
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Au WNS]]
[[Category: Wang K]]

Latest revision as of 19:23, 29 November 2023

Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)

Structural highlights

7d1x is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST2A8_MOUSE Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.[1] [2] [3]

See Also

References

  1. ↑ Feng L, Yuen YL, Xu J, Liu X, Chan MY, Wang K, Fong WP, Cheung WT, Lee SS. Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). J Lipid Res. 2017 Jun;58(6):1114-1131. PMID:28442498 doi:10.1194/jlr.M074302
  2. ↑ Shimohira T, Kurogi K, Liu MC, Suiko M, Sakakibara Y. The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Biosci Biotechnol Biochem. 2018 Aug;82(8):1359-1365. PMID:29685090 doi:10.1080/09168451.2018.1464897
  3. ↑ Wang K, Chan YC, So PK, Liu X, Feng L, Cheung WT, Lee SS, Au SW. Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids. J Lipid Res. 2021;62:100074. PMID:33872606 doi:10.1016/j.jlr.2021.100074

7d1x, resolution 2.50Å

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