5nd2: Difference between revisions
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==Microtubule-bound MKLP2 motor domain in the presence of ADP== | ==Microtubule-bound MKLP2 motor domain in the presence of ADP== | ||
< | <SX load='5nd2' size='340' side='right' viewer='molstar' caption='[[5nd2]], [[Resolution|resolution]] 5.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5nd2]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5nd2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ND2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ND2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nd2 OCA], [https://pdbe.org/5nd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nd2 RCSB], [https://www.ebi.ac.uk/pdbsum/5nd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nd2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KI20A_MOUSE KI20A_MOUSE] Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.<ref>PMID:9438855</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5nd2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5nd2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Kinesin 3D Structures|Kinesin 3D Structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Atherton | [[Category: Large Structures]] | ||
[[Category: Clause | [[Category: Mus musculus]] | ||
[[Category: Cook | [[Category: Atherton J]] | ||
[[Category: Houdusse | [[Category: Clause J]] | ||
[[Category: Joseph | [[Category: Cook A]] | ||
[[Category: Major | [[Category: Houdusse A]] | ||
[[Category: Moores | [[Category: Joseph AP]] | ||
[[Category: Muretta | [[Category: Major J]] | ||
[[Category: Rosenfeld | [[Category: Moores CA]] | ||
[[Category: Sourigues | [[Category: Muretta JM]] | ||
[[Category: Topf | [[Category: Rosenfeld SS]] | ||
[[Category: Yu | [[Category: Sourigues Y]] | ||
[[Category: Topf M]] | |||
[[Category: Yu IM]] | |||
Latest revision as of 15:48, 15 November 2023
Microtubule-bound MKLP2 motor domain in the presence of ADPMicrotubule-bound MKLP2 motor domain in the presence of ADP
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